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Metabolite concentrations were evaluated for their ability to discriminate between SLE and control subjects by partial least squares-discriminant analysis (PLS-DA) using MetaboAnalyst (Xia and Wishart 2011)

TREM2 agonists, such as AL002, promote microglial transformation toward the anti-inflammatory M2 phenotype, thereby reducing the release of pro-inflammatory M1 cytokines (e.g., TNF-, IL-1) and indirectly mitigating inflammation-driven ferroptotic cascades

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One way analysis of variance with Newman-Keuls post test for multiple comparisons was run using Prism 5 software (Graphpad)