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J Atheroscler Thromb 2023;30:74-86.PubMed 76

27 The incorporation of polyunsaturated fatty acids (PUFAs) into membrane lipids first requires the activation of the free fatty acids into PUFA-CoAs by acyl-CoA synthetase long chain family member 4 (ACSL4) and incorporation of the PUFA-CoA into lipids by lysophosphatidylcholine acyltransferase 3 (LPCAT3)

Methods Enzymol 148:350382

This dual action enables coordinated inhibition of leukocyte adhesion, transmigration, and microvascular congestion within the injured kidney (Bonventre and Yang 2011