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Carcinogenesis 23, 735740

Statins inhibit the mevalonate pathway, lowering endogenous CoQ10 levels, which may contribute to statin-associated muscle symptoms (SAMS) ( 3.2 Clinical evidence in heart failure The Q-SYMBIO trial (n = 420)administering 300 mg/day of CoQ10demonstrated improvements in New York Heart Association (NYHA) class, reductions in major adverse cardiovascular events (MACE) (HR 0.50, 95% CI 0.320.80), and lower all-cause mortality in patients with moderate-to-severe heart failure (Xu et al., 2024)

Conflict of Interest Buisson A has received consulting fees from AbbVie, Amgen, Arena, Biogen, Celltrion Healthcare, CTMA, Galapagos/Alfa-Sigma, GutyCare/Resilience Janssen, Lilly, MSD, Nexbiome, Pfizer, Roche, Sandoz, Takeda and Tillotts

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