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The mechanisms targeted by polyphenols are the modulation of the activity of CYP450 liver enzymes (responsible for drug metabolism) or transporter proteins (essential in regulating the bioavailability of drugs)

In this study, we present the design and characterization of the Second Generation Covalent Fragment Library (CovLib Gen2), an expanded collection of 81 structurally diverse electrophiles tailored for Covalent Fragment-Based Drug Discovery (FBDD) using an electrophile-first approach

In this way, novel approaches have been proposed, such as light and social rhythm therapies, which aim to regulate everyday activities, to enhance social relationships and, consequently, reduce the effect of circadian patterns disturbances [46]