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This renal IR evidence is directly pertinent to perioperative AKI risk, particularly in settings featuring transient hypoperfusion or clamp-related ischemia ( Sodium nitrite and Sildenafil are being evaluated for their mitochondria-protective effects via enhancing NO signaling and blood flow, which can reduce reperfusion injury (nitrite can inhibit mitochondrial complex I in a reversible manner to reduce ROS burst on reperfusion)

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doi: 10.1111/1541-4337.12898 41 LongYZhangMMujumdarASChenJ

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Abstract Background Glutathione S-transferases (GSTs) are a superfamily of multifunctional enzymes in living organisms with metabolic and detoxification functions, which can detoxify exogenous and endogenous compounds and thereby reduce the damage caused by toxic substances to the body

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Experiments were performed at least three times with at least three technical replicates in each experiment

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