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Alpha-adrenergic agonists: Limited (and often very small) studies of Clonidine and Guanfacine report improvements in behaviors such as hyperactivity, impulsivity, stereotypies, self-stimulation, inappropriate speech, irritability, aggression, and oppositional behavior as a frequent side effect in individuals with ASD

There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]

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