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Dig Dis Sci 57: 29102916 Burchard J, Zhang C, Liu AM, Poon RTP, Lee NPY, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G et al (2010) microRNA122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma

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Since the energy requirements for glutamate uptake are extremely high, the reversal of glutamate transport is preceded by a decline in astrocytic glutamate uptake, which signifies the earliest astrocytic contribution to the development of glutamate excitotoxicity, together with the already reversed glutamate uptake in neurons (Rossi et al., 2000)

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