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L.KuppeC.MarschE.et al (2022)

doi: 10.1126/sciadv.abq0651

Partial citrate is partially translocated to the cytoplasm through the mitochondrial citrate carrier SLC25A1, and then regenerates mitochondrial oxaloacetate under the cleavage induced by ATP citrate lyase to complete the non-classical TCA cycle process to regulate chromatin dynamics [137, 138]

The APHINITY trial highlighted that adding pertuzumab to trastuzumab and ChT significantly improves iDFS, particularly in patients with high-risk, lymph node-positive tumors 81