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SLIDESHOW See Slideshow 13 causes of premature graying Premature graying may be due to various reasons, such as: Vitamin deficiencies, such as B12, biotin, or folate deficiencies Emotional or mental stress Mineral deficiencies, such as iron or copper deficiencies Thyroid diseases Protein deficiency Genetic diseases, such as neurofibromatosis and tuberous sclerosis Smoking Radiation exposure Alopecia areata (an autoimmune condition that causes patchy loss of pigmented hair) Certain medications Exposure to harsh chemicals Chronic health conditions Excessive calorie restriction or a very low-calorie diet Can you prevent premature graying of hair