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Inhibiting the expression of SHMT1 significantly reduced GCSC sphere formation and enhanced the sensitivity of Drosha knockdown gastric cancer cells to 5-FU [73]

Parkinsons disease (PD) is the most prevalent movement disorder and the second most prevalent chronic neurodegenerative disorder

High ChaC1 expression also serves as a biomarker for adverse outcomes in gastric adenocarcinoma (72), corpus endometrial (73) and breast cancer (74) and uveal melanoma (75)

Commonly used oral agents include methotrexate, cyclosporine, acitretin, and apremilast, each with distinct mechanisms of action and efficacy profiles (Menter et al