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Surprisingly, this additional activity was not recovered in isolated erythrocytes, but only in serum (Figure 2a)

Chronic metabolic stress induces beta cells to adopt a senescence-associated secretory phenotype (SASP), characterised by cytokines and ECM remodelling factors, that spreads into the surrounding environment promoting beta cell failure [57]

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Dietary TMAO precursors such as L-carnitine and choline increased artery hardening in atherosclerosis-prone mice