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doi: 10.1152/ajpcell.1995.269.5.C1112

The classic mechanism of acetaminophen hepatotoxicity is that its reactive metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), depletes GSH and then covalently binds to proteins

Spurious group differences due to head motion in a diffusion MRI study

In addition, , -unsaturated aldehydes and MDA can undergo nucleophilic attack at their carbonyl group to form a Schiff base with the -amino group of Lys ( Figure 1 Of note, although lipid peroxidation is the canonical source of PC, alternative pathways have also been observed