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Shark cartilage as source of antiangiogenic compounds: from basic to clinical research

37 (2), e111

GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

Arogenate-specific TyrA a enzymes have also been identified in some microbes, such as the -proteobacteria Zymomonas mobilis and Phenylobacterium immobile (Mayer et al., 1985