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10.1515/DMDI.2008.23.1-2.69 59 KalaposM

10.1016/j.rdc.2004.04.006 320

In U87-EGFRvIII cells, CDDP reduced viability modestly (85.2%), C-PC alone decreased viability significantly (51.5%) and induced cell death, but the combination did not further increase apoptosis

Thus, there is greater conversion of kynurenine (KYN) into its final product, QA, increasing the production of this neurotoxic metabolite and, indirectly, decreasing KYN bioavailability for the production of the neuroprotective metabolite, kynurenic acid (KynA) (Heisler and OConnor 2015)