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Overrepresented pathways were estimated against the background human scale metabolic model MNF (from MetaboAnalyst Mummichog package) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for Homo sapiens to determine the relative significance of the identified pathways [50]

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6 The potential role of exercise-related irisin in depression 6.1 Irisin regulates energy metabolism Impaired brain energy metabolism has gained increasing attention as a key factor in the pathogenesis of depression (Wu et al., 2016