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2020) and represent another environmental factor with gut barrier-impairing properties

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Treatments targeting ATII cell proliferation and differentiation to ATI cells have not been developed owing to plenty of unknowns regarding the mechanism of alveolar re-epithelialization

The nuclear transcription factor paired box 2 (Pax2), crucial for renal cell proliferation regulation, is overexpressed due to decreased CMA activity, promoting tubular epithelial cell growth and maintaining the hypertrophic state (211)

Overall, available evidence suggests that ferroptosis may contribute to skeletal muscle atrophy across diverse pathological contexts, including CKD, chemotherapy, sepsis and inflammatory states