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UV exposure induces the production of ROS, which subsequently activate the NF-B and MAPK signaling pathways, leading to increased transcription of pro-inflammatory cytokines (IL-1, TNF-, IL-6 and COX-2) and MMP-1, both of which contribute to inflammation and collagen degradation

Importantly, LLO alone was unable to permeabilize LUVs at 0 mol%, 10 mol% or 20 mol% CHOL, whereas it successfully permeabilized them when preincubated with Lm PC-PLC, achieving values similar to those obtained at 40 mol% of CHOL (Fig

Wingard, Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo Study, Diabetes Care , 2002