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When MUT activity is impaired due to genetic mutations or functional vitamin B12 deficiency, methylmalonyl-CoA cannot be efficiently converted into succinyl-CoA

After consideration of public comments, we are finalizing the work RVUs and direct PE inputs for CPT codes 96920, 96921, 96922 as proposed with the exception of the finalized refinements of clinical staff time for the CA024 to 5 minutes and equipment times of 38, 40, and 46 minutes for the power table (EF031) and exam light (EQ168) equipment for CPT codes 96920, 96921, and 96922, respectively, to conform to the increased clinical staff time for CA024

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Effects on maternal bone were observed in pregnant and lactating rats in a pre- and postnatal toxicity study when esomeprazole magnesium was administered at oral doses of 14 to 280 mg/kg/day (about 3.4 to 68 times an oral human dose of 40 mg on a body surface area basis)