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Several studies have shown that regular physical activity increases endothelial vasodilation in people who have high blood pressure and heart disease, as well as in healthy individuals (52, Studies have also shown that exercise increases antioxidant activity, which helps inhibit the breakdown of nitric oxide caused by free radicals ( The benefits of exercise on endothelial health and nitric oxide production can be seen in as little as 10 weeks when exercising for 30 minutes at least three times a week (52)

163 For example, SIRT1-mediated deacetylation of TSC2, an upstream regulator of mTOR, indirectly synchronizes ER stress levels with autophagic activity

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