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Subsequently, radioactivity rapidly declined to 2033% of the peak values within 4 h for most tissues, except the small intestine, which showed a slower decline within 8 h ( 8.4 Bypassing curcumins poor bioavailability The physicochemical properties of curcumin significantly limit its clinical utility, as its poor bioavailability restricts its functional capabilities ( Enhancing curcumins therapeutic potential requires a focus on prolonging its serum bioavailability by increasing its half-life and reducing its metabolic rate ( Figure 5 illustrates the improvement of curcumin bioavailability via integration with drug delivery systems

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Unlike approved drugs, they haven't undergone the rigorous testing required to understand their safety profile in humans