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It has few symptoms during the early stages, so many people do not know they have it until liver damage starts causing problems

The patient population belonged to diverse ethnic backgrounds, reflecting the global prevalence of IGS, notably in Scandinavian and Mediterranean regions, the former primarily due to CUBN [1,2,3,4] gene variant, and the latter often attributed to AMN variants secondary to consanguinity

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108Xeljanz (tofacitinib): Initial clinical trial results of increased risk of major adverse cardiovascular events and malignancies (excluding NMSC) with use of tofacitinib relative to TNF-alpha inhibitors