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Within neurons, excess Fe + undergoes Fenton or HaberWeiss reactions, generating hydroxyl radicals that attack DNA, proteins, and lipid membranes, thereby inducing ROS and lipid peroxidation (183)

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Interestingly, TRIM37-deficient cells become autophagy addicted, and so inhibition of autophagy flux in these cells leads to pronounced cell death (Wang W

However, for those who want to bypass the production step entirely, Liposomal Glutathione is often preferred due to its superior absorption