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Description

Functional inhibition of redox regulated heme proteins: A novel mechanism towards oxidative stress induced by homocysteine

Suggested dose depends on body weight

Ballatori, N

Since supraphysiological levels of NADH were reported to inhibit NAD + -dependent sirtuin deacetylase (SIRT17) (50), accumulated NADH in mitochondria repressed mitochondrial SIRT3 activity leading to hyperacetylation of mitochondrial proteins (42, 47) (Fig