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Although immunohistochemical analyses have found B cell-rich tertiary lymphoid structures in most brains from patients with MS, but not in the two PD patients investigated (92), there is ample evidence for the involvement of B cells, antibodies, and humoral immune effector mechanisms in PD (9395)

However, regardless of this is the isoform with the highest sensitivity to citrate in normal tissues 178 , phosphofructokinase-1 in tumors exhibits reduced sensitivity to citrate, accompanied by increased sensitivity to activation by fructose-1,-6-bisphosphate 179,180,181

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In it, we explore what clinicians are trying, whats working, where barriers remain, and practical strategies for integrating these tools safely and effectively