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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Its broad benefitsranging from bone strength and immune resilience to mood balance and hormonal regulationmake it one of the most valuable therapies in preventive and functional medicine