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The pharmacology of flupirtine and mechanisms of action involved provide a spectrum of effects that would not only control the chronic pain characteristic of fibromyalgia but many of the other symptoms

Glossary 4CL 4-Coumarate-CoA ligase 5-HT 5-Hydroxytryptamine ACC Acetyl-CoA carboxylase AChE Acetylcholinesterase ADH Alcohol dehydrogenase ADT Plant aronic acid dehydratase Akt Protein kinase B ALD Alcoholic liver disease ALDH Acetaldehyde dehydrogenase ALOX15 Arachidonic acid 15-lipoxygenase ALP Alkaline phosphatase ALT Alanine aminotransferase ALT/GPT Alanine aminotransferase AMPK Adenosine 5-monophosphate (AMP)-activated protein kinase APTT Activated partial thromboplastin time AST Aspartate transaminase AST/GOT Aspartate aminotransferase BACE1 Beta-site APP cleaving enzyme 1 BCL 6 B-cell lymphoma 6 BMD Bone mineral density BMSCs Bone marrow mesenchymal stem cells C3 Cysteine-3 C4H Cinnamate 4-hydroxylase CaMK II Calcium/calmodulin kinase II CAT Catalase CCNB 1 Cell cycle protein B1 CHI Chalcone isomerase CHR Chalcone reductase CHS Chalcone synthase COL10A 1 Collagen type X alpha 1 chain COL2A 1 Collagen type II alpha 1 chain COX-2 Cyclooxygenase-2 CREB cAMP-response element binding CRF Corticotropin-releasing hormone receptor CTGF Connective tissue growth factor CTX-1 C-telopeptide of crosslinked collagen type I CWI Cell-wall integrity CYP1B1 Cytochrome P450 family 1 subfamily B member 1 CYP7A1 Cholesterol 7 alpha-hydroxylase DA Dopamine DgpA GenBank: BBG22493.1 DgpBC PDBID: EM Map EMD-30808 DYP Dye-decolorizing peroxidase DZE 0.30 0.02 O

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Comprehensive analysis of the global prevalence and burden of functional gastrointestinal disorders including IBS-C and FC