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In addition, there was an observed increase in the levels of protein expression for markers of microglia (CD11b and Iba-1), as well as an upregulation of factors associated with pyroptosis, namely NLRP3, caspase-1, and ASC following the expression of circHIPK three

Her journey of studying the biochemistry of Down Syndrome began 4 years ago when her son was born with Mosaic Down Syndrome

Journal of Neuroinflammation 7: 72

(27) demonstrated that bioactive cytokines secreted by bones can enter the peripheral circulation and cross the BBB, thus modulating the function and metabolism of the CNS, playing a crucial central regulatory role