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Evans and Lake 1998)

The complexity of bioactive compounds in medicinal plants, variability in preparation processes, and the unpredictability of their absorption, distribution, metabolism, and excretion in the body collectively constitute the primary translational bottlenecks

varium is most active with aromatic cysteine S -conjugates, but some activity is noted with simple alkyl conjugates

There is a very strong body of experimental evidence indicating a neuroprotective role of UA, mediated through anti-inflammatory and antioxidative mechanisms that themselves are likely to be closely interrelated (summarised in Fig