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The Fic domain has been shown to use CDP-choline 34 and UTP 35 as reactants, it is possible that some S-HxxxE proteins may use other nucleotides or their derivatives as substrates for protein modification

These represent the cutting edge of peptide-based autoimmune research, and while most have not yet reached widespread clinical application, their mechanisms and preliminary results warrant serious attention from researchers in this field

An aliquot of the extract was used to determine protein content according to Bradford 49 , using bovine serum albumin as the standard

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