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Based on genotoxicity and cancer studies in laboratory animals, cumene is classified by the National Toxicology Program as Reasonably Anticipated to Be a Human Carcinogen. The xylene isomers are also irritants, particularly of the eyes and upper respiratory tract, as to a lesser extent are toluene and ethylbenzene

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For instance, elevated levels of cell-free mtDNA in the cerebrospinal fluid (CSF) serve as a marker of neuronal damage and mitochondrial stress within the central nervous system

Forebrain deletion of GDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections