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Tissue was collected from the angular gyrus of the parietal association cortex (Brodmann Area 39) due to the susceptibility of this region to A and tau neuropathology during intermediate Braak stages of AD, allowing separation of participants along a clinical spectrum 25,26

The most common way to switch medications is to taper off the current medication for up to a few weeks and then start the new medication at a low dosage and increase it gradually