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You can read the abstract of this article at The idea of Reward Deficiency Syndrome suggests that addiction to various substances occurs because they stimulate the brains reward system so intensely that the population of dopamine D2 receptors (DD2R) decreases

Yoo SP, Pineda F, Barrett JC et al (2016) Gadolinium-functionalized peptide amphiphile micelles for multimodal imaging of atherosclerotic lesions

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4 Safety and metabolic effects of tesamorelinLonger-term safety and metabolic effects, including visceral fat and lipid outcomes