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Zinc plays a crucial role in taste and smell perception

That paper reported no genotoxic findings across an Ames test, a chromosomal aberration assay, and a bone micronucleus assay in rodent models

Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaenovi I, Lastra RR, Curtis M, Yamada SD, Perets R, Mcgregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E (2019) Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

In 2014, the FDA approved this combination (Contrave, Mysimba) for body weight management in adults who are overweight and obese