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JOR Spine 1 , e1036 (2018)

Vitamin B12 is an essential nutrient that plays a crucial role in keeping our bodies healthy and functioning properly

Interestingly, both kinase DYRK1A and Akt have convergent effects by directly inactivating GSK3 by phosphorylation at Thr356 (for DYRK1A) (Song et al., 2015) and on serine 9 (for Akt) (Tlili et al., 2013

A highly sensitive infectivity assay confirmed that several compounds inhibited viral infectivity in a dose-dependent manner, with EC 50 values in the low micromolar range