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Emerging agents like Tirzepatide, which activates both GLP-1 and GIP receptors, and Orforglipron, a nonpeptide oral GLP-1 agonist in phase 2 trials, further expand the therapeutic potential of this class (23)(24)

Rechler and Nissley demonstrated that IGF-II was identical to multiplication stimulating activity, a factor known to stimulate DNA synthesis in chick embryo fibroblasts (11)

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The expression of key regulators of ferroptosis, such as GPX4, SLC7A11, and FSP1, was significantly upregulated, but ACSL4 expression was obviously downregulated in three major types of RCC based on The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases (Fig