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Recently, it has been reported that combination of statins (atorvastatin, fluvastatin and simvastatin) and conventional chemotherapy (topotecan, paclitaxel and doxorubicin) acted synergistically to inhibit cell proliferation and to induce cytotoxicity in an aggressive natural killer cell leukemia (221)

By working on distinct substrate proteins, DUBs play a role in several biological processes, including cell proliferation, differentiation, and apoptosis

Sustained inflammatory activation can, in turn, promote hepatic stellate cell (HSC) activation and extracellular matrix deposition, thereby contributing to fibrogenesis