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Increased gut-derived SCFAs into the systemic circulation can permeate the BBB, but the accurate mechanisms by which these affect neural function yet remain unclear

Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75