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CRC Press Olsen RKJ, Cornelius N, Gregersen N (2015) Redox signalling and mitochondrial stress responses

By inhibiting oxidative phosphorylation (OXPHOS), which induces mitochondrial hyperpolarization and subsequently stimulates ROS production [23], the oxidation of palmitoylcarnitine (C16-carnitine) produces more ROS in mitochondria than carbohydrates [24]

Among people with moderate-to-severe obstructive sleep apnea and obesity, tirzepatide reduced the AHI, body weight, systolic blood pressure, and improved sleep-related patient-reported outcomes