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doi: 10.1152/ajpregu.00858.2006

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The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimotos thyroiditis by Mahdieh Abbasalizad Farhangi and Siroos Tajmiri The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis TherapyCurrent Reports by Zielisk, et al

Furthermore, vascular endothelial injury and endothelial cell dysfunction in PCOS patients are independent of age, body weight, and metabolic abnormalities, suggesting that PCOS may be an independent risk factor for CVDs and could lead to an earlier onset of CVDs despite the presence of metabolic disorders (97, 98).The current consensus is that chronic inflammation of the vascular endothelium and the resulting endothelial dysfunction are fundamental to the pathogenesis of CVDs (99, 100)