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Biochemical features were different from previously reported cases, including complex IV deficiency in addition to the classically reported complex I, II, and III deficiencies [15]

doi: 10.1016/j.sjbs.2020.10.030

38 Collectively, all these discoveries have contributed not only to our understanding of the biological aging process, but also allowed to develop rationale intervention strategies to target molecular hallmarks of this process and biomarkers to quantify biological aging status, aiming to achieved healthy lifespan extension with precise and multitargeted approaches

Duailibi MS, Cordeiro Q, Brietzke E, Ribeiro M, LaRowe S, Berk M, et al