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SCUBE2 expression and secretion are associated with osteoblast differentiation and bone metastasis in human tumors, and both targeting Hedgehog signaling with Sonidegib and targeting SCUBE2 with neutralizing antibodies can effectively inhibit bone metastasis in multiple metastasis models (67)

2014;5(10):e1505

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Taken together, the safety profile of SS-31-based compounds in patients, together with the preliminary success with acute treatment in the setting of HF with reduced EF, suggest that antioxidant peptide-mediated mitochondrial ROS scavenging holds promise for use in the clinical setting