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In stroke research, for example, models that incorporate hypertensive or diabetic phenotypes have demonstrated significantly altered responses to neuroprotective interventions compared to normotensive controls, underscoring the critical importance of patient-specific biological contexts [575]

Why susceptibility to HSV differs from person to person HSV establishes lifelong latency in nerve cells, so the question of susceptibility is really two questions: how easily a person becomes infected, and how well their immune system keeps the virus in check afterward