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The reduction of Fe 3+ /Cu 2+ by intracellular GSH can further amplify ROS levels, while the depletion of GSH in turn inhibits GPX-4-mediated antioxidant responses to induce ferroptosis, thereby enhancing therapeutic efficacy (Huang H

The European Food Safety Authority (EFSA) has updated its guidance (in 2021) to outline a tiered risk assessment approach for nanomaterials in food/feed, covering key areas like particle characterization, exposure estimation, toxicological testing, and genotoxicity evaluation (219222)

While some trials test brand-new treatments, others study ways to make current treatments work better, or focus on reducing over-treatment by shortening the course of care or replacing older therapies that have long-term risks

Neural Regen Res 4(2):9297 Wu Z-Z, Li Y-H, Huang ACJ, Li M, Zhang X-L, Wang J-G, Yang M, Chen M-Y (2010) Endoplasmic reticulum stress induced by tunicamycin and antagonistic effect of Tiantai No