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Although fundamental 5A-1MQ and LD-mediated changes to the microbiome were identified, this work is similar to many current studies where further investigations will clarify if changes in the microbiome are causative or associative 100

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Indeed, in addressing modeling of future APF-GCC interactions, it is also meritorious to highlight this note that the contemporaneous predictive studies have been validated in limited geographical regions, therefore it is imperative to conduct large-scale multinational investigations for better understanding of GCC impacts on future APF mycoflora and global pattern of AFs distribution (68)