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In summary, this study demonstrates that calcium overload plays a critical role in the cytotoxicity associated with a-synucleinopathy, leading to mitochondrial damage, lysosomal dysfunction, and cell death

10.1016/j.jneuroim.2005.09.012 34 NakajimaK.TohyamaY.MaedaS.KohsakaS.KuriharaT

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18 , 19 , 20 Furthermore, a high expression of STAT3 alters the cell cycle 21 , 22 and inhibits the apoptosis by upregulating anti-apoptotic signaling 23 , 24 in inflammation-associated CRC and other human cancers