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The top eight pathways that impacted the bubble map were phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, histidine metabolism, starch and sucrose metabolism, arginine and proline metabolism, arginine biosynthesis, glutathione metabolism, and purine metabolism

Cathepsin B-sensitive peptide linkers, hyaluronic acid-based nanoparticles, ATP-responsive liposomes and micelles, and 4-Phenylbutyric acid-modified hyaluronic acid-based nanoparticles are engineered to release pharmaceuticals in reaction to enzyme activity, enzymatic degradation by hyaluronidase, elevated ATP levels in metabolically active tumor cells, and esterase activity in 4-PBA-modified hyaluronic acid-based nanoparticles (79)

Nature 417 , 447452 (2002)