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4, luteolins ability to suppress cell growth, trigger apoptosis, arrest the cell cycle, inhibit angiogenesis, and modulate critical pathways such as MAPK, Wnt/-catenin, NF-B, and PI3K/Akt [87] marks its potential as an anti-fibrotic agent

These compounds are thought to interact with cellular receptors involved in tissue recovery, potentially supporting collagen synthesis and dermal hydration

Discussion In humans, little is known about skatole effects on the expression of drug-metabolizing enzymes in the liver

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