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Bioorg Chem 163:108670

Enzymes supporting phase 2 detoxification reactions, such as those involved in the biosynthesis of glutathione (e.g., -glutamylcysteine synthetase or GCS) and its conjugation to substrates (e.g., glutathione S -transferases or GSTs), are rapidly induced following exposure to stressful stimuli

Glycine The Quiet Engine of Detox Supports: liver conjugation, bile acid clearance, collagen stability Specializes In: PFAS aldehydes, pesticide intermediates, mitochondrial organic acids Why it matters: glycine becomes rate-limiting when toxin load is chronic Processed diets and chronic chemical exposure burn through glycine faster than the body can replace it, slowing glutathione assembly

Actors and factors in the resolution of intestinal inflammation: lipid mediators as a new approach to therapy in inflammatory bowel diseases