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[DOI] [PMC free article] [PubMed] 38.Bonomini M., Pandolfi A., Di Liberato L., Di Silvestre S., Cnops Y., Di Tomo P., D'Arezzo M., Monaco M.P., Giardinelli A., Di Pietro N., et al

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Increasing before steady state means you are adjusting the dose before you even know how the current dose actually affects you