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Lipolysis requires that soluble lipases access the highly hydrophobic TAG substrate and that hydrophobic products of this reaction be removed

8,9 Given the limitations of current testing for vitamin B 12 deficiency, and because its administration is inexpensive and fairly innocuous, many clinicians have a low threshold for prescribing vitamin B 12 supplementation (usually by intramuscular injection to bypass issues with absorption)

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(simple regression for the healthy subgroup without adjustment for sex is provided in Supplementary Fig